myocardium (Total 443 Patents Found)

The present invention relates to new pyridine derivatives of formula: ##STR1## wherein R 1 is an alkyl or an alicyclic group, R 2 and R 3 are alkyls or alicyclic groups or form an heterocycle with the atom of nitrogen to which they are bonded; the invention also relates to a process for the preparation of said deriv...
The present invention provides a novel bifurcated stent for providing retrograde flow of oxygenated blood from the left ventricle to the myocardium via the coronary sinus without a significant or deleterious left-to-right shunt. The present invention includes a main covered stent and a side limb, generally contemplatin...
A novel method for expressing a protein which comprises: transforming skeletal myoblasts or cardiac myocytes with a DNA sequence comprising a DNA segment encoding a selected gene downstream of the Rous sarcoma virus long terminal repeat or the expression sequence in pRSV, and implanting said skeletal myoblasts or cardi...
Various system embodiments comprise a neural stimulator, a pulse generator, and a controller. The neural stimulator is adapted to generate a neural stimulation signal. The pulse generator is adapted to generate a pacing signal to provide myocardium pacing. The controller is adapted to control the neural stimulator and ...
An electrical lead for a cardiac device includes a body having a distal end sized for insertion through a catheter, first and second electrodes extending through the body, with each electrode terminating in a tip having proximal and distal ends and arranged to extend to an area of cardiac tissue. The tips include a ful...
Methods, compositions, and kits for repairing damaged myocardium and/or myocardial cells including the administration of cytokines, variants of cytokines, cardiac stem cells, or combinations thereof are disclosed and claimed. In addition, methods, compositions, and kits for forming coronary vasculature including the ad...
Cardiac myocyte differentiation reported thus far is from iPS cells generated from mice and human fibroblasts. iPS cells from cardiac or ventricular specific cell types are generated herein having the potential to repair and regenerate infarcted myocardium. The cells were transduced with four sternness factors and repr...
Accurate mapping of electrophysiologic activation within the human heart is achieved for discrete areas within the myocardium by utilizing a catheter having at least one pair of orthogonal sensors disposed on the catheter. Orthogonal sensors, which are comprised of two or more electrodes generally disposed circumferent...
The invention provides compositions and methods for protectiong vascular tissues from injury that occurs, for example, during occlusion of one or more arteties. In some embodiments, the injury is myocardial infarction. The compositions of the invention include combinations of platelet derived growth factor, vascular en...
The present invention relates to derivatives of piperidinedione of formula: ##STR1## in which R is alkyl or forms with N a possibly substituted morpholino or piperidino group, n=2 or 3, R 1 , R 2 , R 3 and R 4 represent H or lower alkyl; R 3 and R 4 taken together may represent (CH 2 ) m where m=4 or 5 and R 2 an...
Catheter system (9) with centrally located drug delivery catheter (20) is adapted to be implanted at a depth within the left ventricular apex (15) of the heart (10). Hollow penetrating structure (30) penetrates the heart muscle from the endocardial side. The delivery catheter is navigated into the endorcardial space of...
Provided is a method of treating coronary artery disease in a mammal, comprising administering to a region of the heart of the mammal (a) a first vector encoding one or more angiogenic proteins which induce vascularization in the heart of the mammal, and (b) a second vector encoding one or more cardio-differentiating t...
A method for the prevention and treatment of stunning of the heart subsequent to ischemia-reperfusion is described. The method comprises administering a therapeutically effective amount of a phospholamban inhibitor to a patient. Phospholamban inhibitors relieve the inhibitory effect of phospholamban on cardiac sarcopla...
Systems and methods evaluate electrical contact between the myocardium and one or more electrodes inside the heart. The systems and methods electrically sense electrical contact between the myocardium and electrodes and generate unitary contact-indicating outputs indicating the presence or absence of electrical contact...
Various system embodiments comprise a neural stimulator, a pulse generator, and a controller. The neural stimulator is adapted to generate a neural stimulation signal. The pulse generator is adapted to generate a pacing signal to provide myocardium pacing. The controller is adapted to control the neural stimulator and ...
Implantable device comprises means for detection of muscular activity of the myocardium using at least one ventricular probe. The device further provides means for stimulation of the myocardium. The device detects a reduction in blood flow by recording and analyzing the ventricular repolarization....
Provided is a mutant protein capable of binding specifically and quickly to troponin I derived from human myocardium. The mutant protein comprises a first mutant scFv antibody fragment 51 a second mutant scFv antibody fragment 52 and a linker 53 . The first mutant scFv antibody fragment 51 comprises a first ligh...
Various system embodiments comprise a neural stimulator, a pulse generator, and a controller. The neural stimulator is adapted to generate a neural stimulation signal. The pulse generator is adapted to generate a pacing signal to provide myocardium pacing. The controller is adapted to control the neural stimulator and ...
The invention provides compositions comprising modified stem cells containing a transgene that affects the expression of at least one gene that inhibits or promotes cardiomyogenesis. In particular, the invention discloses compositions comprising cardiac stem cells, wherein said cardiac stem cells comprise a transgene e...
The invention provides a modified version of alpha B-Crystallin (αBC), and methods for delivering this modified version of alpha B-Crystallin (αBC) to tissues and cells; the invention provides a modified version of αBC in which the serine at position 59 has been changed to glutamate to mimic phosphorylation and the ...
A system and method for preservation and transport of a donor heart are provided, which includes features for improving the refreshment of the myocardium and for removing toxic catabolites, thereby lengthening the available time for effective transport. The invention utilizes a housing with a perfusion subsystem for re...
Cells are cultured on a cell culture support having a substrate surface coated with a temperature-responsive polymer whose upper or lower critical solution temperature in water is 0∼80°C, and subsequently, (1) the temperature of the culture solution is brought to above the upper critical solution temperature or belo...
The present invention provides improved systems and methods for the minimally invasive treatment of heart tissue deficiency, damage and/or loss, especially in patients suffering from disorders characterized by insufficient cardiac function, such as congestive heart failure or myocardial infarction. In certain embodimen...
FIELD: medicine. SUBSTANCE: method involves supplying laser radiation impulses to patient heart. The radiation is focused over the epicardial surface of the myocardium. Non-perforating canal is formed. Pulsating laser radiation of 1-1.1 mcm wave length is applied in multiple modulation mode and quality factor modulatio...
Methods, compositions, and kits for repairing damaged myocardium and/or myocardial cells including the administration cytokines are disclosed and claimed. Methods and compositions for the development of large arteries and vessels are also disclosed and claimed. The present application also discloses and claims methods ...
A segmented cine MR pulse sequence of the “TrueFISP”-type having a short repetition time TR is used to acquire MR data during a single breath hold. In the resulting cine images, the blood and the myocardium have distinctly different image contrasts....
A method for differentiation of normal myocardium from diffuse disease using T mapping includes acquiring one or more images of a patient by an imaging apparatus, generating a T1 map from the one or more images, defining a region of interest within the one or more images, determining the average T1 value within the reg...